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NS 1738

Product Name
NS 1738
CAS No.
501684-93-1
Chemical Name
NS 1738
Synonyms
NS 1738;NSC 213859;NS 1738 (NSC 213859);1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea;N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea;Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-;NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
CBNumber
CB42455756
Molecular Formula
C14H9Cl2F3N2O2
Formula Weight
365.13
MOL File
501684-93-1.mol
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NS 1738 Property

Boiling point:
344.1±42.0 °C(Predicted)
Density 
1.617±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
White crystalline solid.
pka
8.08±0.13(Predicted)
color 
Off-White to Light Grey
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05983
Product name
NS1738 - CAS 501684-93-1 - Calbiochem
Packaging
10MG
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
21018
Product name
NS 1738
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21018
Product name
NS 1738
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
21018
Product name
NS 1738
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
Tocris
Product number
2995
Product name
NS1738
Purity
≥99%(HPLC)
Packaging
50
Price
$702
Updated
2021/12/16
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NS 1738 Chemical Properties,Usage,Production

Description

NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.

Uses

NS 1738 is a selective a7 nAchR allosteric modulator.

Biological Activity

Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .

storage

Store at RT

NS 1738 Preparation Products And Raw materials

Raw materials

Preparation Products

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NS 1738 Suppliers

China 49 India 1 United Kingdom 2 United States 8 USA 1 Global 61
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
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60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

501684-93-1, NS 1738Related Search:

NS1652 NS1643 NS-6180 NS 1738

  • NS 1738
  • N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea
  • NSC 213859
  • 1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea
  • Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-
  • NS 1738 (NSC 213859)
  • NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
  • 501684-93-1